abstract：:Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-gr...

journal_title：Genes

authors： Tan Z,Dong W,Ding Y,Ding X,Zhang Q,Jiang L

更新日期：2019-12-30 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen and an important cause of livestock infections. More than 20 staphylococcal enterotoxins with emetic activity can be produced by specific strains responsible for staphylococcal food poisoning, one of the most common food-borne diseases. Whole genome sequencing provides a...

journal_title：Genes

authors： Macori G,Bellio A,Bianchi DM,Chiesa F,Gallina S,Romano A,Zuccon F,Cabrera-Rubio R,Cauquil A,Merda D,Auvray F,Decastelli L

更新日期：2019-12-27 00:00:00

abstract：:This special issue of Genes demonstrates clearly that research in epigenetics has proceeded at a very rapid pace in the last decade. [...]. ...

journal_title：Genes

authors： Grunau C,Le Luyer J,Laporte M,Joly D

更新日期：2019-12-23 00:00:00

abstract：:Rust caused by the fungus Puccinia helianthi and downy mildew (DM) caused by the obligate pathogen Plasmopara halstedii are two of the most globally important sunflower diseases. Resistance to rust and DM is controlled by race-specific single dominant genes. The present study aimed at pyramiding rust resistance genes ...

journal_title：Genes

authors： Qi L,Ma G

更新日期：2019-12-20 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is an extremely aggressive disease with a high metastatic potential. Most patients are diagnosed with metastatic disease, at which the five-year survival rate is only 3%. A better understanding of the mechanisms that drive metastasis is imperative for the development of better therapeu...

journal_title：Genes

authors： Ayres Pereira M,Chio IIC

更新日期：2019-12-19 00:00:00

abstract：:The transcription factor PAX6 is essential in ocular development in vertebrates, being considered the master regulator of the eye. During eye development, it is essential for the correct patterning and formation of the multi-layered optic cup and it is involved in the developing lens and corneal epithelium. In adultho...

journal_title：Genes

authors： Lima Cunha D,Arno G,Corton M,Moosajee M

更新日期：2019-12-17 00:00:00

abstract：:Osteoarthritis (OA) is a widely prevalent disease worldwide, and with an increasingly ageing society, it has become a challenge for the field of regenerative medicine. OA is a disease process involving multiple joint tissues, including those not visible on radiography, and is a complex disease process with multiple ph...

journal_title：Genes

authors： Borić I,Hudetz D,Rod E,Jeleč Ž,Vrdoljak T,Skelin A,Polašek O,Plečko M,Trbojević-Akmačić I,Lauc G,Primorac D

更新日期：2019-12-17 00:00:00

abstract：:Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and autism spectrum disorder, and among those with fragile X syndrome, approximately 1/3rd meet a threshold for an autism spectrum disorder (ASD) diagnosis. Previous functional imaging studies of fragile X syndrome have typically fo...

journal_title：Genes

authors： McKechanie AG,Campbell S,Eley SEA,Stanfield AC

更新日期：2019-12-17 00:00:00

abstract：:Since ancient times, the importance of physical activity (PA) and of a wholesome diet for human health has been clearly recognized. However, only recently, it has been acknowledged that PA can reverse at least some of the unwanted effects of a sedentary lifestyle, contributing to the treatment of pathologies such as h...

journal_title：Genes

authors： Di Liegro I

更新日期：2019-12-16 00:00:00

abstract：:The revolution in next-generation DNA sequencing technologies is leading to explosive data growth in genomics, posing a significant challenge to the computing infrastructure and software algorithms for genomics analysis. Various big data technologies have been explored to scale up/out current bioinformatics solutions ...

journal_title：Genes

authors： Shi L,Wang Z

更新日期：2019-12-06 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is a reliable and easily detectable reproductive marker for the fertility competence of many farm animal species. AMH is also a good predictor of superovulation in cattle, sheep, and mares. In this review, we have summarized the recent findings related to AMH and its predictive reliability...

journal_title：Genes

authors： Umer S,Zhao SJ,Sammad A,Weldegebriall Sahlu B,Yunwei P,Zhu H

更新日期：2019-12-04 00:00:00

abstract：:Vavilovia formosa is a relict leguminous plant growing in hard-to-reach habitats in the rocky highlands of the Caucasus and Middle East, and it is considered as the putative closest living relative of the last common ancestor (LCA) of the Fabeae tribe. Symbionts of Vavilovia belonging to Rhizobium leguminosarum bv. vi...

journal_title：Genes

authors： Chirak ER,Kimeklis AK,Karasev ES,Kopat VV,Safronova VI,Belimov AA,Aksenova TS,Kabilov MR,Provorov NA,Andronov EE

更新日期：2019-12-01 00:00:00

abstract：:EuAP2 genes are well-known for their role in flower development, a legacy of the founding member of this subfamily of transcription factors, whose mutants lacked petals in Arabidopsis. However, studies of euAP2 genes in several species have accumulated evidence highlighting the diverse roles of euAP2 genes in other as...

journal_title：Genes

authors： Solomon CU,Drea S

更新日期：2019-12-01 00:00:00

abstract：:Elite athlete status is a partially heritable trait, as are many of the underpinning physiological, anthropometrical, and psychological traits that contribute to elite performance. In recent years, our understanding of the specific genetic variants that contribute to these traits has grown, such that there is consider...

journal_title：Genes

authors： Pickering C,Kiely J,Grgic J,Lucia A,Del Coso J

更新日期：2019-11-26 00:00:00

abstract：:Testis cords are the embryonic precursors of the seminiferous tubules. Development of testis cords is a key event during embryonic testicular morphogenesis and is regulated by multiple signaling molecules produced by Sertoli cells. However, the exact nature and the cascade of molecular events underlying testis cord de...

journal_title：Genes

authors： Zheng W,Nazish J,Wahab F,Khan R,Jiang X,Shi Q

更新日期：2019-11-26 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a progressive hereditary muscular disease with X-linked recessive inheritance, that leads patients to premature death. The loss of dystrophin determines membrane instability, causing cell damage and inflammatory response. Macrophage migration inhibitory factor (MIF) is a cytokine t...

journal_title：Genes

authors： Lombardo SD,Mazzon E,Mangano K,Basile MS,Cavalli E,Mammana S,Fagone P,Nicoletti F,Petralia MC

更新日期：2019-11-18 00:00:00

abstract：:The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA subunit is present in two major splicing isoforms, NF-YAl ("long") and NF-YAs ("short"). Little is known about the expression levels of NF-Y subunits in tumors, and nothing in lung cancer. By interrogating RNA-seq TCGA and GEO datasets,...

journal_title：Genes

authors： Bezzecchi E,Ronzio M,Dolfini D,Mantovani R

更新日期：2019-11-17 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:While methods for detecting SNVs and indels in circulating tumor DNA (ctDNA) with hybridization capture-based next-generation sequencing (NGS) have been available, copy number variations (CNVs) detection is more challenging. Here, we present a method enabling CNV detection from a 150-gene panel using a very low amount...

journal_title：Genes

authors： Peng H,Lu L,Zhou Z,Liu J,Zhang D,Nan K,Zhao X,Li F,Tian L,Dong H,Yao Y

更新日期：2019-11-14 00:00:00

abstract：:Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemi...

journal_title：Genes

authors： Prins FM,Said MA,van de Vegte YJ,Verweij N,Groot HE,van der Harst P

更新日期：2019-11-07 00:00:00

abstract：:During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organ...

journal_title：Genes

authors： Reich S,Weinstein DC

更新日期：2019-11-06 00:00:00

abstract：:DNA methylation patterns have been shown to change throughout the normal aging process. Several studies have found epigenetic aging markers using age predictors, but these studies only focused on blood-specific or tissue-common methylation patterns. Here, we constructed nine tissue-specific age prediction models using...

journal_title：Genes

authors： Choi H,Joe S,Nam H

更新日期：2019-11-04 00:00:00

abstract：:Plant tissue culture methods, such as somatic embryogenesis, are attractive alternatives to traditional breeding methods for plant propagation. However, they often suffer from limited efficiency. Somatic embryogenesis receptor kinase (SERK)1 is a marker gene of early somatic embryogenesis in several plants, including ...

journal_title：Genes

authors： Luan A,He Y,Xie T,Chen C,Mao Q,Wang X,Li C,Ding Y,Lin W,Liu C,Xia J,He J

更新日期：2019-11-01 00:00:00

abstract：:In this work, we have shown that Novosphingobium tardaugens NBRC 16725 (strain ARI-1), a bacterial strain that was isolated due to its capacity to mineralize the estrogenic endocrine compound 17β-estradiol, is also able to mineralize testosterone, the androgenic endocrine compound. Using in silico analysis, we predict...

journal_title：Genes

authors： Ibero J,Galán B,Díaz E,García JL

更新日期：2019-10-31 00:00:00

abstract：:The Himalayas are one of earth's hotspots of biodiversity. Among its many cryptic and undiscovered organisms, including vertebrates, this complex high-mountain ecosystem is expected to harbour many species with adaptations to life in high altitudes. However, modern evolutionary genomic studies in Himalayan vertebrates...

journal_title：Genes

authors： Hofmann S,Kuhl H,Baniya CB,Stöck M

更新日期：2019-10-31 00:00:00

abstract：:The plant circadian clock coordinates environmental signals with internal processes including secondary metabolism, growth, flowering, and volatile emission. Plant tissues are specialized in different functions, and petals conceal the sexual organs while attracting pollinators. Here we analyzed the transcriptional str...

journal_title：Genes

authors： Terry MI,Carrera-Alesina M,Weiss J,Egea-Cortines M

更新日期：2019-10-30 00:00:00

abstract：:The complete mutational spectrum of dystrophinopathies and limb-girdle muscular dystrophy (LGMD) remains unknown in Mexican population. Seventy-two unrelated Mexican male patients (73% of pediatric age) with clinical suspicion of muscular dystrophy and no evidence of DMD gene deletion on multiplex polymerase chain rea...

journal_title：Genes

authors： Alcántara-Ortigoza MA,Reyna-Fabián ME,González-Del Angel A,Estandia-Ortega B,Bermúdez-López C,Cruz-Miranda GM,Ruíz-García M

更新日期：2019-10-29 00:00:00

abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...

journal_title：Genes

authors： Rick K,Ottewell K,Lohr C,Thavornkanlapachai R,Byrne M,Kennington WJ

更新日期：2019-10-28 00:00:00

abstract：:Information on the biochemical pathways of carbon and energy metabolism in representatives of the deep lineage bacterial phylum Deferribacteres are scarce. Here, we report the results of the sequencing and analysis of the high-quality draft genome of the thermophilic chemolithoautotrophic anaerobe Deferribacter autotr...

journal_title：Genes

authors： Slobodkin A,Slobodkina G,Allioux M,Alain K,Jebbar M,Shadrin V,Kublanov I,Toshchakov S,Bonch-Osmolovskaya E

更新日期：2019-10-26 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome that results from dominant loss-of-function mutations mainly in the NF1 gene. Large rearrangements are present in 5-10% of affected patients, generally encompass NF1 neighboring genes, and are correlated with a more severe NF1 phenotype. Evident genoty...

journal_title：Genes

authors： Brussa Reis L,Turchetto-Zolet AC,Fonini M,Ashton-Prolla P,Rosset C

更新日期：2019-10-24 00:00:00

abstract：:The sea lamprey (Petromyzon marinus) is one of few vertebrate species known to reproducibly eliminate large fractions of its genome during normal embryonic development. This germline-specific DNA is lost in the form of large fragments, including entire chromosomes, and available evidence suggests that DNA elimination ...

journal_title：Genes

authors： Timoshevskiy VA,Timoshevskaya NY,Smith JJ

更新日期：2019-10-22 00:00:00

abstract：:Oral clefts are composed of cleft of the lip, cleft of the lip and palate, or cleft of the palate, and they are associated with a wide range of expression and severity. When cleft of the palate is associated with cleft of the lip with preservation of the primary palate, it defines an atypical phenotype called disconti...

journal_title：Genes

authors： Demeer B,Revencu N,Helaers R,Gbaguidi C,Dakpe S,François G,Devauchelle B,Bayet B,Vikkula M

更新日期：2019-10-22 00:00:00

abstract：:Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...

journal_title：Genes

authors： Zhang L,Feng S,Duan G,Li Y,Liu G

更新日期：2019-10-17 00:00:00

abstract：:Cyclocarya paliurus (Batal.) Iljinskaja, a unique species growing in southern China, is a multi-function tree species with medicinal, healthcare, material, and ornamental values. So far, sexual reproduction is the main method for extensive cultivation of C. paliurus plantations, but this is limited by low seed plumpne...

journal_title：Genes

authors： Chen X,Mao X,Huang P,Fang S

更新日期：2019-10-17 00:00:00

abstract：:Balanced chromosome rearrangements are one of the main etiological factors contributing to hypoprolificacy in the domestic pig. Amongst domestic animals, the pig is considered to have the highest prevalence of chromosome rearrangements. To date over 200 unique chromosome rearrangements have been identified. The factor...

journal_title：Genes

authors： Donaldson B,Villagomez DAF,Revay T,Rezaei S,King WA

更新日期：2019-09-30 00:00:00

abstract：:Transcriptional responses to the appropriate temporal pattern of action potential firing are essential for long-term adaption of neuronal properties to the functional activity of neural circuits and environmental experience. However, standard transcriptome analysis methods can be too limited in identifying critical as...

journal_title：Genes

authors： Iacobas DA,Iacobas S,Lee PR,Cohen JE,Fields RD

更新日期：2019-09-26 00:00:00

abstract：:The autophagy-lysosome pathway, which involves many crucial genes and proteins, plays crucial roles in the maintenance of intracellular homeostasis by the degradation of damaged components. At present, some of these genes and proteins have been identified but their specific functions are largely unknown. This study wa...

journal_title：Genes

authors： Wu LX,Wei CC,Yang SB,Zhao T,Luo Z

更新日期：2019-09-25 00:00:00

abstract：:Variants of the LOXHD1 gene, which are expressed in hair cells of the cochlea and vestibule, have been reported to cause a progressive form of autosomal recessive non-syndromic hereditary hearing loss, DFNB77. In this study, genetic screening was conducted on 8074 Japanese hearing loss patients utilizing massively par...

journal_title：Genes

authors： Maekawa K,Nishio SY,Abe S,Goto SI,Honkura Y,Iwasaki S,Kanda Y,Kobayashi Y,Oka SI,Okami M,Oshikawa C,Sakuma N,Sano H,Shirakura M,Uehara N,Usami SI

更新日期：2019-09-23 00:00:00

abstract：:Feed cost accounts for approximately 65-75% of overall commercial pork production costs. Therefore, improving the feed efficiency of pig production is important. In this study, 12 individuals with either extremely high (HE) or low (LE) feed efficiency were selected from 225 Duroc × (Landrace × Yorkshire) (DLY) pigs. A...

journal_title：Genes

authors： Wang X,Li S,Wu J,Ding R,Quan J,Zheng E,Yang J,Wu Z

更新日期：2019-09-18 00:00:00

abstract：:B-cell acute lymphoblastic leukemia is the most commonly diagnosed childhood malignancy worldwide; more than 50% of these cases are diagnosed in Mexico. Although the five-year survival rate is >80%, 30% of patients experience relapse with poor prognosis. Cancer-associated gene expression profiles have been identified ...

journal_title：Genes

authors： Rosa R,Villegas-Ruíz V,Caballero-Palacios MC,Pérez-López EI,Murata C,Zapata-Tarres M,Cárdenas-Cardos R,Paredes-Aguilera R,Rivera-Luna R,Juárez-Méndez S

更新日期：2019-09-16 00:00:00